Protective Effect of Methylprednisolone Against Cisplatin-Induced Ototoxicity: Comparison of Route of Administration

Materials and Methods: Thirty-five adult, albino guinea pigs were randomly divided into 5 groups and were treated as follows: Group (1) received cisplatin alone 13 mg/kg, (2) intratympanic methylprednisolone alone, (3) cisplatin and intratympanic methylprednisolone, (4) intravenous methylprednisolone alone, (5) cisplatin and intravenous methylprednisolone. Baseline and 72 hours post-treatment distortion product otoacustic emissions were measured. Cochleae were harvested and processed for electron microscopic examination after completion of auditory testing.